injectible creatine

[bestia]

have you guys ever heard of injectable creatine.

[bigriggs00]

Originally Posted by bestia

have you guys ever heard of injectable creatine.

Uhhh, no.....

[staggerlee]

FORMS OF CREATINE

Creatine is found naturally in foods, particularly in meat. For early research with creatine supplementation, the creatine was extracted from animal flesh - an expensive process. Today, commercial creatine supplements are produced through chemical synthesis in North America, Asia, and Europe.

Although creatine synthesis is a proprietary process among manufacturers, it is quite common to use another muscle-related compound, sarcosine (or sarcosinate salts), as the principal starting material for the commercial synthesis of creatine. As with creatine synthesis, the starting material used is also synthetically produced. Sarcosine is a component of human metabolism; chemically it is N-methylglycine (a relative of glycine, one of the precursor amino acids in the body’s production of creatine).The synthetic chemical cyanamide is also used as a primary starting material. Organic solvent-water mixtures are used as the reaction medium. The purification process removes any residual amounts of reaction components and intermediates.

Creatine monohydrate is the most commonly available creatine supplement and the form primarily used in most research studies. However, other forms are available. Creatine phosphate is sold in small quantities. It is an extremely expensive form of creatine, which likely curtails its widespread distribution and use. Any effect of creatine phosphate ingested orally would be mediated by creatine alone, since gut phosphatase enzymes would readily cleave off the phosphate portion of the molecule, liberating FCr. Additionally, serum possesses high phosphatase activity, leading to rapid breakdown of intravenously administered creatine phosphate to creatine and phosphate (Saks and Strumia 1993). Limited data suggest that PCr infusions may enhance physical training intensity (Clark 1996), and only a few published studies have used oral creatine phosphate to evaluate its effects on exercise performance or health. Creatine phosphate is used in various countries as an injectable drug primarily for medical reasons. However, as Clark (1996) notes, the use of intravenous PCr must be undertaken only under the guidance of a qualified physician.

Creatine monohydrate is the most commonly available creatine supplement and the form primarily used in most research studies. However, other forms of creatine are available, such as creatine citrate and creatine phosphate.

Creatine citrate is another form of creatine sold as a supplement; here too there appear to be no published studies showing differences in absorption, muscle creatine retention, or functional parameters such as changes in muscle performance or body composition.

Commercial creatine supplements are available in a variety of forms, including powder, tablets, gel, liquid, chewing gum, and candy. Some commercial products blend creatine monohydrate with other substances such as carbohydrate, proteins, vitamins and minerals, amino acids, and even herbal extracts and phytochemicals.

Commercial creatine supplements are available in a variety of forms, including powder, tablets, gel, liquid, chewing gum, and candy. Micronized creatine, designed to dissolve better in fluid, leave less residue in the cup, and enhance intestinal absorption, is also available. Because some studies have indicated that glucose, sodium, and taurine may enhance creatine uptake by the muscle cell (Kreider et al. 1997b), some commercial products blend creatine monohydrate with other substances. For example, PhosphagainTM contains carbohydrate, protein, fat, creatine, taurine, yeast-derived RNA, and L-glutamine. Other commercial products contain dietary proteins, vitamins, and minerals, other amino acids and biochemicals, and even herbal extracts and phytochemicals.

Quality control ensuring the purity of creatine monohydrate employs various analytical chemistry techniques, including high-performance liquid chromatography (HPLC), high-performance capillary electrophoresis (HPCE), fluorescence detection, and various "wet" chemical quantification methods. Creatine monohydrate intended for use as a dietary supplement should be subjected to analytical methods characterized by high specificity and sensitivity (HPLC and HPCE) for each production run.

Dietary supplements containing creatine should list the ingredients on the label, along with recommended daily dosages. Hopefully this listing may provide the buyer with accurate information relative to the actual contents in the supplement, as is not always the case in the dietary supplement industry. Although the implementation of quality control and assurance in production of creatine (or any other dietary supplement) is not mandated by any state or federal regulatory agency (Food and Drug Administration, for example) in North America, most companies appear to require some form of validation of purity from primary creatine manufacturers and suppliers. In choosing a creatine-containing dietary supplement, it is advisable that the prospective buyer request from the distributor independent laboratory analysis records for more than one recent lot of material sold. This request can be made with any distributor of creatine supplements. Plisk and Kreider (1999) have recommended one request the following to obtain quality assurance when purchasing creatine supplements:

1. The product should be manufactured in a USFDA-inspected facility complying with pharmaceutical ’Current Good Manufacturing Practices’ (the code of federal regulations describing methods, equipment, facilities, and controls used for manufacturing, processing, packing, or holding drugs and foods). This also means that it should comply with ’Manufacturing Practices for Nutritional Supplements.’
2. A manufacturer’s (not distributor’s or importer’s) certificate of analysis should be provided for random samples from the same batch/lot number on the containers being purchased. Different laboratories may not test for each physical constant listed below, and typical values may vary slightly (hence none are indicated here). However, the vendor takes a big step toward establishing credibility simply by providing this type of documentation:
* appearance (white to pale cream solid)
* assay (determined with HPCE or HPLC methods)
* bulk density
* mesh size
* microbiological/pathogenic contamination (e.g., coliforms, e. coli, salmonella, aureus, yeasts/molds) and plate count
* poisons (e.g., arsenic) and heavy metals (e.g., lead, mercury)
* residual moisture/loss on drying
* residue on ignition (for inorganic materials)



Reputable manufacturers who adhere to these industry standards typically do not hesitate to share this information with potential distributors or vendors.

Dietary supplements containing creatine should list the ingredients on the label, along with recommended daily dosages. Quality-control information should be obtainable from the manufacturer.

[DrMax]

Last I read, creatine is not stable in liquid for anyways.

This would mean you would have to make a bach of liquid creatine everytime you would want to inject it.

But I have never heard of injecting it though,.

[contrl]

That's just plain silly. Even if it were 100% safe to inject, the benefits reaped from creatine are hardly worth the trouble.

[suk35]

Who needs another compound to inject anyway. I'll stick to the old fasion power.

[upondeez]

I could only imagine the pain from the gritty creatine!

[fulforb]

I can honestly saw I have never heard of that one on any board or magazine.

[brinkman]

haha never hard of it, sounds retarded, why take the time and risk and scar tissue to inject something you can drink in 20 seconds...

[etxlifter]

well pretty pointless as creatine needs to be ph balanced to really work well.


if some of you guys dont think creatine works well try using the creatine recipe in btpb. helps alot.