|
MGF is a splice variant of the IGF produced by a frame shift in the IGF gene. It exhinits local effects in skeletal muscle and w/out modification is not systematic which means it cant travel through the body. MGF increases muscle stem cell count, so that more may fuse and become part of adult or mature muscles. This is a process required for maturing or adult muscle cells to continue growing.
MGf appears to have a dual action in that like other IGF-I isoforms, it upregulates protein sysnthesis as well as activating satellite cells. However the latter rold of MGF is probably more important as most of the mature IGF-I will be derived from the IGF-IEa during the second phase repair. Needless to say it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introducecd by IM injection. This resulted in a 20% increase in the weight of the injected muscle within just 2 weeks, and the analyses showed that this was due to an increase in the size of muscle fibers (goldspink, 2001).
When using MGF a form of IGF you should add AAS or IGF-1 so the new satellite cells that either go dormant or fuse with muscle get stimulation and you will get a synergistically effect and see better results than any of them taken individually. By increasing the cell availability and cell fusion you are going to have synergistic increases in overall muscle.
|
01-06-2008, 07:09 PM
Linear Mode
