Igf & mgf

[thunder]

This was written by FinaFreak.

Most of us are familiar with the peptides Insulin-Like Growth Factor (IGF) and Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells and helps drop body fat and MGF helps facilitate this muscle growth and fat loss.

In the beginning:

When IGF first made its way onto the bodybuilding scene most people were injecting it every day and noticed that after somewhere around 30 days the effects of IGF wore off. This was blamed on receptor "down-regulation" or "desensitization". To combat this people started a 5-on 2-off rotation and then went to a post workout only rotation which extended the time on IGF an additional 10-20 days. But the problem with the lack of "receptor response" was still present.

Then MGF came onto the scene. MGF was suppose to be the next best thing in bodybuilding. It was suppose to be more anabolic than AAS and better suited for building new muscle than IGF, the problem was that it wasn't. Because of its instability it was quickly broken down once injected into the body, to prevent this PegMGF was created. This new MGF was now able to survive in the body from anywhere in the 1-3 days. Combining this new peptide discovery with IGF was suppose to be able to make all of us the next Mr. Olympia. But what happened? Why do we not see a flood of new pros?

What happened:

In theory these two peptides should cause some great results, the problem is they do not work together very well unless your timing is spot on (I will go into greater detail later). In short stem cells in the presence of MGF will cause the cells to split and multiply. When the cells are multiplying they cannot form new tissue and the effects of IGF are completely blocked. So the two together are not very compatible.

Then why not just use IGF? Well most do use IGF only and get great results, but there is that pesky business of receptor "down-regulation" or "desensitization" and you have to end a cycle of IGF after 30-50 days and there is no way to prevent it... or is there?

The science:

In a natural system (Our Body) we have peaks and dips with MGF and IGF levels. The reasons for these peaks and dips are to create the ideal amount of cells to repair and create new tissue. After strenuous exercise the levels of MGF in the body (more specifically in the muscle just trained) increase dramatically and there is a dramatic decrease of IGF levels. The reason for this is because MGF causes stem cells to proliferate (split and multiply). This process ensures that there are enough cells available to make repairs and to create new tissue in order for the tissue to function efficiently and properly (in this case skeletal muscle tissue). As mentioned above in the presence of MGF there is no need for IGF because it is rendered useless and cannot activate the stem cells, so this explains the bodies response to decrease IGF levels.

In 12-36 hours MGF levels begin to drop and there is a direct correlation in the rise of IGF levels within the body. Stem cells have proliferated and now the IGF will bind to the proper receptors and cause differentiation (force the stem cells to form into a specific cell for a specific tissue type). This process repeats every time you exercise and keeps the natural system in an efficient state.

When flooding the body with these artificial peptides a person will change this natural system dramatically. A person using MGF only is causing stem cell proliferation while at the same time preventing IGF to perform its duties of creating new tissue from those newly created stem cells. A person using IGF only is depleting the supply of stem cells at a rate much faster than the body can keep up, leading to a depletion of available stem cells and not receptor "down-regulation" or "desensitization."

This sounds like a lose-lose situation. You are throwing off your body's final tuned muscle repairing mechanism, depleting valuable stem cells or creating too many stem cells for your body to deal with. Why bother?

The climax:

The reason why we bother is because we want to reach or goals. We want to be the biggest bodybuilder, the best powerlifter or whatever it is that we are training so hard for. These peptides are a great addition to our arsenal, but learning to use them properly is the key to utilizing their benefits.

The key is retraining the way we think about MGF and IGF. We have to understand that we are dealing with the creation and depletion of stem cells that are going to be responsible for our muscular growth. Our bodies do not have a constant supply of these stem cells and our bodies will not naturally utilize all of the stem cells it has created. Since we are trying to artificially manipulate the amount and utilization of these stem cells we have to look at this is a different manner.

While we may never get the exogenous MGF and IGF levels just right so that we may counteract the depletion of the stem cells we can adjust our protocols in a way that will increase the amount of time a person can use and respond to both peptides.

The Conclusion Part 1, MGF:

We know that the PegMGF will stay in the body for several days and we know that while in the presence of MGF stem cells will proliferate and the use of IGF is futile. We also know that MGF without the peg is of little to no help because of how quickly exogenous MGF is broken down within the body. So what are the options?

Well both can be of use! PegMGF can be of great use as long as the individual using the peptide in conjuction with IGF understands that the two peptides must be injected in a manner that falls outside of the current way of thinking. And MGF without the Peg addition can also be utilized as long as you don't mind being a pin cushion.

The key with MGF is to learn to either follow your bodies natural peaks and dips of MGF levels and force proliferation on a larger scale with MGF, or to force a longer period of cell proliferation with the use of PegMGF. The key is you have to have stem cells in order to create new muscle tissue.

The Conclusion Part 2, IGF:

Now that we have hit the MGF part of the cycle, now we move into the part of the cycle that utilizes the stem cells. Again we want to either follow the body's natural peaks and dips of IGF levels or we are going to want to cause a prolonged forced differentiation phase. The latter of the two options is simply following standard protocol of everyday injections or 5-on 2-off. The other is all about timing. We know that MGF levels peak in the body after strenuous exercise, so why would you want to inject a substance that is useless in the presence of MGF right when MGF levels are at their highest? The answer is you don't! You will want to wait and inject the IGF 24hrs after the exercise. This will give ample time for the MGF peak to start to dip and can closely mimic the natural rise in IGF levels. This will allow for a person to use a more efficient dose since the timing of the IGF will correspond closely to the dip in MGF levels resulting in greater utilization of the exogenous IGF.

The cycles:

There are a few cycles I would recommend.

The first being IGF only. It works, maybe not the most efficient plan out there but it does work none-the-less.

The second would be the PegMGF/IGF combination. This is not the most efficient methos but should significantly increase the amount of time one can be on an MGF/IGF cycle and still see positive results. (This may have to be altered according to your training schedule)

Sunday - Off Training - Mid-day PegMGF 200-300mcg
Monday - Training (Afternoon)
Tuesday - Off Training - Afternoon IGF 40-80mcg
Wednesday - Training (Afternoon)
Thursday - Off Training - Afternoon IGF 40-80mcg
Friday - Training (Afternoon)
Saturday - Off Training - Afternoon IGF Injection 40-80mcg

The addition of the PegMGF will cause an increase in amount and duration of stem cell proliferation and should subside about the period of the first IGF injection. While this will not keep stem cell levels stable it should prevent the drastic decrease in stem cell numbers seen with IGF only cycles and should significantly increase cycle length.

The third would be the use of regular MGF plus the addition of IGF and woulld closely mimic the natural system.

Sunday - Off Training
Monday - Training (afternoon) - 1hr PWO MGF 50mcg in muscles trained
Tuesday - Off Training - Afternoon IGF 40-80mcg
Wednesday - Training (Afternoon) - 1hr PWO MGF 50mcg in muscles trained
Thursday - Off Training - Afternoon IGF 40-80mcg
Friday - Training (Afternoon) - 1hr PWO MGF 50mcg in muscles trained
Saturday - Off Training - Afternoon IGF 40-80mcg

This protocol should closely mimic natural peaks and dips in MGF and IGF within the specific muscles being trained. While regular MGF is short lived in the body the addition on the regular MGF 1 hour post workout should cause an increase in cell proliferation beyond the natural system's ability and should create a larger pool of stem cells for the utilization of IGF therapy.

[AVEC]

make this a sticky..lol

[thunder]

Aother bit of info on Mgf written by Juggernaut333

Figured this would come in handy for ppl,some excellent info I have come across in my research...applicable info for pegylated mgf as well.just the dosage protocols are different...enjoy

BTW,,The biggest thing to be addressed imo with mgf and ppl not getting results stems from two main problems imo.
1-not using enough and expecting high dose results!a couple hundred mcg may get u some results.but hit 500mcg eod before bed of peg and then tell me u dont start poppin out after they mature and start growin in a month or so
2-expecting things RIGHT NOW!it doesnt work like that folks.you are creating new muscle cells that need a few weeks,perhaps even a month or more to even get mature enough to begin to grow!ok?keep this timeline in mine and watch for it...

Mechano Growth Factor (MGF)

Introduction

Mechano Growth Factor (MGF): a local growth factor or a local tissue repair factor. MGF is derived from the insulin-like growth factor (IGF-1), but its sequence differs from the systemic IGF-1 produced by the liver. MGF is expressed as a form of IGF-1 by mechanically overloaded muscle when mechanical resistance is applied to muscles (such as weight training). At this point, the IGF-1 gene is spliced to produce IGF-1Ec (which is another name for MGF). It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite cells[1]. This production of MGF can stimulate satellite cells into activation, to create new muscle fiber[2]. MGF also promotes nitrogen retention and new protein synthesis. It could actually be the case that this particular expression of MGF (IGF-1Ec) is an important part of the deciding factors in whether a muscle will grow or not. The introduction of this peptide, either by weight training or by an injection, will cause the affected area to respond by producing new muscle tissue. It would be safe to say that MGF presence in the muscle is one of the most major factors in the anabolic effect of resistance training (weight training). Currently, this compound is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth.

Effects

MGF is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth. The most relevant rodent data has been shown that MGF is a very potent inducer of muscle growth when it’s introduced into the muscle via an intramuscular injection of cDNA. In fact, in one study MGF caused a 20% increase in the weight of the injected muscle within 2 weeks[3]. Further investigation elucidated that this was actually due to an increase in the size of the muscle fibers[4].

Mechanism

MGF is extremely likely to cause myogenesis during skeletal muscle hypertrophy by contributing to at least by three important molecular processes: increased satellite cell activity, gene transcription and protein translation. Satellite cells in skeletal muscle provide the extra nuclei for postnatal growth[5] and that they are also involved in repair and regeneration following local injury of muscle fibers[6]. In normal adult undamaged tissue, the satellite cells are quiescent and usually detected just beneath the basal lamina. When activated, they commence to coexpress myogenic factors, including c-met, myoD, myf5, and, later, myogenin[7]. When introduced either by weight training or by an injection，MGF appears to stimulate satellite cells into activation. This in turn allows the activation of extra undamaged nuclei required for muscle fiber growth and repair to occur. In addition, the appearance of MGF initiates the upregulation of new protein synthesis. After this initial and short lived burst of splicing, IGF-1 production switches towards producing a systemic release of IGF-1Ea from the liver, which upregulates protein synthesis as well, but over a longer time line. During this process of regenerating muscle, myoblasts are formed to replace and hypercompensate for damaged/destroyed ones, and then they can either fuse with each other to form totally new myofibers or become incorporated into previously damaged (surviving) myofibers. Ultimately, if more myofibers are created than were destroyed (by training) new muscle growth is experienced.

Dosage and Administration

Its a good way for bodybuilders and other athletes to increase muscle weight by shooting MGF immediately post workout. At this point natural levels of MGF are already elevated. The addition of extra MGF should push more satellite cells towards the formation of new muscle tissue. Administration dosage of MGF should be at about 400mcgs/day, which is injected into the primary muscle trained post workout - half going into that muscle on one side of the body, the other half going into the mirror image of that muscle on the other side. We suggest that a administration of IGF-1, such as IGF-1 Long R3, an hour after shooting of MGF will produce the additional activation of satellite cells, protein translation, and gene transcription. It will force the body to produce much more new tissue than if MGF or IGF are used at any other point during the day, or in a different sequence. It seems that MGF and IGF-1 appear to act synergistically and promote rapid new muscle growth.

Differences between MGF, IGF-1 and HGH (human growth hormone)

HGH is actually closely related to IGF-1, in a lot of ways. HGH, or GH in short, is certainly an effective fat burner and anabolic agent, and is a protein secreted by the pituitary. Once secreted, it has the ability to influence various cells in the body to increase in number and size, as well as having the ability to enhance the movement of amino acids through cell membranes- thereby increasing the rate at which the cells can convert those molecules to usable proteins. It also causes cells to preferentially burn fat in lieu of carbohydrates. The important thing to realize is that there is a mounting body of evidence that strongly suggests that these effects occur as a result of the IGF-1 released as a result of the pituitaries GH secretion. Scientists have discovered that many of HGH’s anabolic and regenerative effects are actually mediated by IGF-1. HGH indirectly causes muscle growth by stimulating the release of IGF-1 when it (the HGH) is destroyed in the human body. So one way you could look at it as HGH being a precursor to IGF-1. The later is more effective at directly causing muscle growth and density increases than HGH. Over the past few decades, HGH has developed quite a reputation for taking awhile (often several weeks) for the user to start seeing results. In contrast, IGF-1 often begins to product noticeable results within the first couple of weeks. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF-1. IGF-1’s superiority to HGH is not only intuitive at some level, but has also been clearly elucidated clinically as well. In the following graphs taken from a rodent study comparing IGF-1 and HGH, a low dose as well as a high dose of IGF-1 was shown to be more anabolic than HGH. In comparison to HGH, IGF-1 produced an overall greater total protein content within the injected muscle as well as a greater final weight of the that muscle (called the "Tibialis Anterior" or TA)[8]:

[JiantJay]

just started IGF by itself. this info is helpful! Just to clarify, I dont want to inject IGF until 24 hrs after a workout since mgf levels are natuarally at their highest? What if my training schedule is mon-thurs?

[thunder]

Igf can be ran m,w,f pwo or ed pwo.

[DrMax]

Thanks for the great read Thunder.

[jens.pulver]

If Igf-Lr3 last in the body 1-3 days, why would you want to shoot it at all ig you are using MGF or PEGMGF? If you worked out every other day, they would still interfere, wouldn't they?

[mr_b]

what about doing a cycle rotation of PEGmgf only with an igf only cycle straight after??

would that work spending a few weeks increasing stem cells with the PEGmgf followed by a few weeks creating the new tissue with the IGF and before the stem cells become completely used up the cycle repeats??

rather than working completely on timing them right cycle the two peptides seperately for short periods like doing 2-3 weeks on each peptide??

[healthgreen]

Thanks for the info have been looking for it all over the place

[bevo]

good read

[DrMax]

My IFG & MGF cycle is going good for me.

[cpt316]

how good is good?

[DrMax]

Originally Posted by cpt316

how good is good?

The IGF and MGF has leaned me out a little bit.
I haven't changed my diet or carido so it is safe to say that I have lost some fat due to the cycle.

I have only been shooting my shoulders.
I have noticed growth in them as well.
The growth isn't crazy but very noticeable.

I am hopeing that enough new muscle cells have grown so that when I shoot the gear again the growth will be that much more powerful.

Overall I think the IGF and MGF cycle is worth it.

[cpt316]

awesome man, I am planning on using both next year for the first time, hopefully it will help propel me to the national level.

[DrMax]

I try to stay away from going to high in dosing.
The GH Gut scares me. I dont want to look like i'm carring a child.

I shoot 25mcg IGF in each shoulder post work out 4 days a week.
Then I take 200mcg MGF once a week post work out.

I also draw 10IU of Slin in each needle.