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Aother bit of info on Mgf written by Juggernaut333
Figured this would come in handy for ppl,some excellent info I have come across in my research...applicable info for pegylated mgf as well.just the dosage protocols are different...enjoy
BTW,,The biggest thing to be addressed imo with mgf and ppl not getting results stems from two main problems imo.
1-not using enough and expecting high dose results!a couple hundred mcg may get u some results.but hit 500mcg eod before bed of peg and then tell me u dont start poppin out after they mature and start growin in a month or so
2-expecting things RIGHT NOW!it doesnt work like that folks.you are creating new muscle cells that need a few weeks,perhaps even a month or more to even get mature enough to begin to grow!ok?keep this timeline in mine and watch for it...
Mechano Growth Factor (MGF)
Introduction
Mechano Growth Factor (MGF): a local growth factor or a local tissue repair factor. MGF is derived from the insulin-like growth factor (IGF-1), but its sequence differs from the systemic IGF-1 produced by the liver. MGF is expressed as a form of IGF-1 by mechanically overloaded muscle when mechanical resistance is applied to muscles (such as weight training). At this point, the IGF-1 gene is spliced to produce IGF-1Ec (which is another name for MGF). It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite cells[1]. This production of MGF can stimulate satellite cells into activation, to create new muscle fiber[2]. MGF also promotes nitrogen retention and new protein synthesis. It could actually be the case that this particular expression of MGF (IGF-1Ec) is an important part of the deciding factors in whether a muscle will grow or not. The introduction of this peptide, either by weight training or by an injection, will cause the affected area to respond by producing new muscle tissue. It would be safe to say that MGF presence in the muscle is one of the most major factors in the anabolic effect of resistance training (weight training). Currently, this compound is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth.
Effects
MGF is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth. The most relevant rodent data has been shown that MGF is a very potent inducer of muscle growth when it’s introduced into the muscle via an intramuscular injection of cDNA. In fact, in one study MGF caused a 20% increase in the weight of the injected muscle within 2 weeks[3]. Further investigation elucidated that this was actually due to an increase in the size of the muscle fibers[4].
Mechanism
MGF is extremely likely to cause myogenesis during skeletal muscle hypertrophy by contributing to at least by three important molecular processes: increased satellite cell activity, gene transcription and protein translation. Satellite cells in skeletal muscle provide the extra nuclei for postnatal growth[5] and that they are also involved in repair and regeneration following local injury of muscle fibers[6]. In normal adult undamaged tissue, the satellite cells are quiescent and usually detected just beneath the basal lamina. When activated, they commence to coexpress myogenic factors, including c-met, myoD, myf5, and, later, myogenin[7]. When introduced either by weight training or by an injection，MGF appears to stimulate satellite cells into activation. This in turn allows the activation of extra undamaged nuclei required for muscle fiber growth and repair to occur. In addition, the appearance of MGF initiates the upregulation of new protein synthesis. After this initial and short lived burst of splicing, IGF-1 production switches towards producing a systemic release of IGF-1Ea from the liver, which upregulates protein synthesis as well, but over a longer time line. During this process of regenerating muscle, myoblasts are formed to replace and hypercompensate for damaged/destroyed ones, and then they can either fuse with each other to form totally new myofibers or become incorporated into previously damaged (surviving) myofibers. Ultimately, if more myofibers are created than were destroyed (by training) new muscle growth is experienced.
Dosage and Administration
Its a good way for bodybuilders and other athletes to increase muscle weight by shooting MGF immediately post workout. At this point natural levels of MGF are already elevated. The addition of extra MGF should push more satellite cells towards the formation of new muscle tissue. Administration dosage of MGF should be at about 400mcgs/day, which is injected into the primary muscle trained post workout - half going into that muscle on one side of the body, the other half going into the mirror image of that muscle on the other side. We suggest that a administration of IGF-1, such as IGF-1 Long R3, an hour after shooting of MGF will produce the additional activation of satellite cells, protein translation, and gene transcription. It will force the body to produce much more new tissue than if MGF or IGF are used at any other point during the day, or in a different sequence. It seems that MGF and IGF-1 appear to act synergistically and promote rapid new muscle growth.
Differences between MGF, IGF-1 and HGH (human growth hormone)
HGH is actually closely related to IGF-1, in a lot of ways. HGH, or GH in short, is certainly an effective fat burner and anabolic agent, and is a protein secreted by the pituitary. Once secreted, it has the ability to influence various cells in the body to increase in number and size, as well as having the ability to enhance the movement of amino acids through cell membranes- thereby increasing the rate at which the cells can convert those molecules to usable proteins. It also causes cells to preferentially burn fat in lieu of carbohydrates. The important thing to realize is that there is a mounting body of evidence that strongly suggests that these effects occur as a result of the IGF-1 released as a result of the pituitaries GH secretion. Scientists have discovered that many of HGH’s anabolic and regenerative effects are actually mediated by IGF-1. HGH indirectly causes muscle growth by stimulating the release of IGF-1 when it (the HGH) is destroyed in the human body. So one way you could look at it as HGH being a precursor to IGF-1. The later is more effective at directly causing muscle growth and density increases than HGH. Over the past few decades, HGH has developed quite a reputation for taking awhile (often several weeks) for the user to start seeing results. In contrast, IGF-1 often begins to product noticeable results within the first couple of weeks. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF-1. IGF-1’s superiority to HGH is not only intuitive at some level, but has also been clearly elucidated clinically as well. In the following graphs taken from a rodent study comparing IGF-1 and HGH, a low dose as well as a high dose of IGF-1 was shown to be more anabolic than HGH. In comparison to HGH, IGF-1 produced an overall greater total protein content within the injected muscle as well as a greater final weight of the that muscle (called the "Tibialis Anterior" or TA)[8]:
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