Archive for February 2015

Bodybuilding with Mechano growth factor

MGF-mechano-growth-factor

Bodybuilding with Mechano growth factor

MGF (mechano growth factor) has been used by bodybuilders and athletes for a few years already. After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.

MECHANO GROWTH FACTOR Background

It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano growth factor (MGF) as compared to IGF-1.

What does MGF do?

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

From Studies done on MGF

In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase.

It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

Peptide GHRP-2 for bodybuilding

Peptide, GHRP-2, bodybuilding, CJC-1295

GHRP-2 for bodybuilding

The effects of GHRP-2 are GH secretion stimulation, appetite promotion, fat mass decrease and muscle mass increase, lowering of cholesterol level, skin and bones state improving, defense of the liver and anti-inflammatory action.

DOSE USED WITH GHRP-2:

The dose should be 300 mgs each day. These cjc1295 doses should be injected 3 times a day. Starting with one injection in the morning . The injections are usually made subcutaneously in an abdominal area. The time between injections should be atleast 3-4 hours (in order the body has the time to produce GH for further release). Do not consume food for between 15-30 minutes after your dosage. Best time is around 20-25 minute mark. GH pulses should peak within about 10 minutes after dosage. Fats and Carbohydrates affect the pulse dramatically. Protein has no effect on pulse. However, you can have a pure protein source in your stomach at anytime if choose to do so.

How to take GHRP-2 during a Cycle:

Each day would consist of
100mcg of CJC-1295
+
100-200 mcg GHRP-2
three times a day.
at
in the morning on an empty stomach 25 minutes before eating
in the afternoon – PWO
finally just before bed

Dilution or reconstitution of GHRP-2 :

GHRP-2 is a peptide which is bought in powdered form. In order to inject this compound, it must be reconstituted through the use of either sterile water or bacteriostatic water. Both are acceptable re-constitutional ingredients, however the use of sterile water will see the GHRP-2 degrade at a faster rate than bacteriostatic water. Mixing (reconstitution) the lyophilized product in their vials with Bacteriostatic Water (BW) can take some getting used to. The idea is not to add too much dilution. The typical rule of thumb is to add 0.5mL of BW to 1mg of Peptide. So a 2mg vial should reconstitute with 1mL BW. 5mg with 2.5mL, 10mg with 5mL, etc. Squirt the BW along the inside wall of the vial in a smooth controlled manner being cautious not to agitate the mixture too much. It will dissolve itself and become clear. You can roll the vial gently between your fingers or hands but don’t shake it to dissolve. The reconstitute is ok to be drawn once fully dissolved.